THREE-DIMENSIONAL QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIPS AND DOCKING STUDIES OF SOME STRUCTURALLY DIVERSE FLAVONOIDS AND DESIGN OF NEW ALDOSE REDUCTASE INHIBITORS

Aldose reductase (AR) plays an important role in the development of several long-term diabetic complications.Inhibition of AR activities is a strategy Banners for controlling complications arising from chronic diabetes.Several AR inhibitors have been reported in the literature.Flavonoid type compounds are shown to have significant AR inhibition.The

This research explores Goal Neck the development of a modular prefabricated concrete housing prototype, focusing on sustainability and flexibility.Supported by industry collaboration, it examines three key hypotheses: (1) a rigid geometric modular layout optimizing standardized panels while allowing spatial customization and adaptability, (2) a mix